High levels of IGFBP‐6 in ST may be relevant for immune cell chemoattraction into the inflamed synovia; indeed, in vitro experiments confirmed that IGFBP‐6 acts as chemoattractant for RA immune cells, in particular T lymphocytes, and that this effect was partially inhibitable by dexamethasone. This evidence concerns the gene IGFBP6 and rheumatoid arthritis.