IGFBP‐6 is capable, however, of actions independent of IGF‐II, including regulation of proliferation, apoptosis, angiogenesis and cell migration.10, 42 For example, IGFBP‐6 was shown to be effective at attenuating the IGF‐II‐mediated increase in cell contractility of fibroblasts obtained from Dupuytren's disease (DD) patients, while it inhibited DD fibroblast proliferation through mechanisms that are independent of IGF‐II sequestration.43 Here, IGFBP6 is linked to dentin dysplasia.