It has been demonstrated that Suv39H1 is overexpressed in gastric cancers and knocking‐down Suv39H1 could suppress gastric cancer development, which is in accordance with our results here.28 In addition to the interactions between epigenetic modulation by Suv39H1 and miR‐125a‐5p uncovered in the current study, it has also been demonstrated HDACs and Sirtuins are also involved into this process.13, 25, 26 Overexpessing miR‐125a‐5p could self‐activate the silenced miR‐125a‐5p in gastric cancer cells, resulting in cancer suppression in vitro and in vivo. The gene discussed is SUV39H1; the disease is gastric cancer.