CD4 and neoplasm: As a subpopulation of T cells, CD4 memory resting T cells could further differentiation and been given a various function, including aid CD8+ T cells in tumor rejection, suppressing harmful immunological reactions to self‐ and foreign antigens and even blocking CD8+ T‐cell activation and NK cell killing.45, 46 Thus, it can be seen that CD4 memory resting T cells play a pivotal role in the development of CRC and its direction of differentiation could be a potential therapeutic target.