FOXP3 and colorectal carcinoma: For instance, one study provided evidence for a role of FoxP3+ Treg density in CRC tissue as predictor of prolonged survival.19 While in another study, the expression of Tregs surface markers cluster (FoxP3, TGF‐b, IL‐10) was not associated with a particular outcome.20 These results were validated by genomic and in situ immunohistochemistry analyses.