There are reports in the postrenal transplantation malignancy in Taiwan, especially on the analysis of risk factors and incidence of specific solid malignancy.11, 12 The effect of mTOR inhibitors on postrenal transplantation malignancy is still elusive in Taiwan, although there was evidence of combination of low‐dose mTOR inhibitors with CNI for avoiding post‐transplantation malignancy.24 Therefore, the aim of this study is to answer whether the immunosuppressive agent, especially mTOR inhibitor, plays a role in the occurrence of the post‐transplantation malignancy. Here, MTOR is linked to cancer.