POSTN and cholesteryl ester measurement: POSTN, encoding secreted matricellular protein Periostin, is critical for epithelial‐mesenchymal transition, tumor angiogenesis, and metastasis.26 A pioneer radiogenomic study found that POSTN was the top upregulated gene that could reflect edema/cellular invasion, and revealed that high expression of POSTN resulted in poor overall survival and progression‐free survival in GBM patients.27 MZ‐1, a neutralizing monoclonal antibody to POSTN, showed significant growth inhibition both in vivo and in vitro,28 thereby providing an alternative approach in clinical management of CE patients.