POSTN, encoding secreted matricellular protein Periostin, is critical for epithelial‐mesenchymal transition, tumor angiogenesis, and metastasis.26 A pioneer radiogenomic study found that POSTN was the top upregulated gene that could reflect edema/cellular invasion, and revealed that high expression of POSTN resulted in poor overall survival and progression‐free survival in GBM patients.27 MZ‐1, a neutralizing monoclonal antibody to POSTN, showed significant growth inhibition both in vivo and in vitro,28 thereby providing an alternative approach in clinical management of CE patients. Here, POSTN is linked to neoplasm.