Transcript analysis of additional prototypical AR‐regulated genes FKBP5, KLK2, NKX3.1, and TMPRSS2 shows a similar pattern of expression to PSA and Ki67 (Fig. 3E), indicating general inhibition of androgen signaling by bicalutamide in prostate cancer PDEs. This evidence concerns the gene FKBP5 and Familial prostate cancer.