ADAM10 and renal fibrosis: As PAX2 was observed to induce EMT in renal tubular epithelial cells, and PAX2 could regulate ADAM10 in several cell types, we hypothesized that PAX2 may regulate ADAM10 activity in the renal tubular epithelia, and that ADAM10 might be implicated in the pathogenesis of EMT and renal fibrosis.