As it has been previously reported, when we analyzed the levels of CD4+CD25highFoxp3+ Treg cells, significant lower levels of these lymphocytes were observed in patients with SLE or RA compared to healthy controls, both in the case of LSI or HSI individuals (p < 0.05 in all cases, Figure 2(a)). This evidence concerns the gene CD4 and systemic lupus erythematosus.