In addition, Scrivo et al. observed that a low-sodium dietary regimen is associated with a significant reduction of CD4+CD45RA−Foxp3low lymphocytes in patients with RA as well as with a reduction in Th17 cells with an enhancement in Foxp3+ Treg cells in patients with SLE [24]. The gene discussed is CD4; the disease is systemic lupus erythematosus.