Polymer nanoparticles loaded with paclitaxel and targeted to CD133 (CD133NPs) on Caco-2 colorectal adenocarcinoma cells were shown to effectively reduce the number of cells and the formation of colonies in vitro and also demonstrated better therapeutic effects in the xenograft model of breast cancer compared to the treatment with free paclitaxel [121]. Here, PROM1 is linked to breast carcinoma.