Due to the fact that frequent ALK-wt overexpression in primary neuroblastoma tumors was associated with a poor clinical outcome, similarly to the presence of activating ALK mutations such as ALK-F1174L and ALK-R1275Q [62–64], it was suggested that excess expression of ALK-wt may be involved in oncogenesis and progression of neuroblastoma. The gene discussed is ALK; the disease is neuroblastoma.