A multiple tumor tissue microarray conducted on 128 different types of tumors showed that most of L1CAM-positive tumors have neuroectodermal and neural crest origin, and among these tumors, 96% neuroblastomas, 93% granular cell tumors, 76% pheochromocytomas, 86% schwannomas, 54% primitive neuroectodermal tumors, 40% paragangliomas, and 56% of GISTs are strictly positive for L1CAM [153]. The gene discussed is L1CAM; the disease is hereditary pheochromocytoma-paraganglioma.