It is also supported by another finding that there is a significant relationship between early levels of soluble biomarkers and exhausted CD4/activated CD8 T cells via systematic analysis of correlation between soluble inflammatory biomarker expression and CD4/CD8 T cells at the different stages of HIV infection (including PHI, CHI, and UT-CHI) in HIV-infected Mozambican adults [105]. The gene discussed is CD8A; the disease is HIV infectious disease.