Here, we showed that changes of BTLA and HVEM expressions in peripheral blood CD4+ and CD8+ T cells from HCC patients were different; BTLA expression was significantly upregulated on circulating CD4+ but not CD8+ T cell subset, while HVEM expression was significantly downregulated on circulating CD8+ but not CD4+ T cell subset. Here, CD4 is linked to hepatocellular carcinoma.