The serum levels of TNF-alpha showed significant increase after PSE (from 2.4 ± 2 pg/ml to 3.0 ± 2 pg/ml: ∗p = 0.0077, by Wilcoxon's test) compared to before PSE, as did the serum level of sTNFr-I (from 1997.3 ± 603 pg/ml to 2392.0 ± 701 pg/ml: ∗p = 0.0022, by Wilcoxon's test). This evidence concerns the gene TNF and photosensitive epilepsy.