Probably in the early developing of DM and in the patients of younger age, we can see the initiation of the so-called “metabolic preconditioning.” The mechanisms of this phenomenon can be connected with increase of the expression of antioxidant protection factors and enzymes of PI3K/Akt signaling pathways and with decrease of the expression of apoptosis genes, proinflammatory cytokines (TNF-α), profibrogenic transforming growth factor-β, and alpha actin-1—a hypertrophy marker [17]. Here, TNF is linked to diabetes mellitus.