INS and obesity due to melanocortin 4 receptor deficiency: SBF is influenced by numerous factors in a complex interplay between, for example, site of injection, temperature, exercise, obesity, body position, blood pressure, use of vasodilating/vasoconstricting drugs, and smoking, many of which have been reported to influence the pharmacokinetic profile of insulin [10, 111, 113–129] (Table 3).