The 1639 genes targeted by the 7 miRNAs in SDVonly are significantly enriched (raw p value < 0.05) in 6 KEGG pathways (calcium signaling pathway, salivary secretion, amyotrophic lateral sclerosis (ALS), MAPK signaling pathway, PPAR signaling pathway, and Alzheimer's disease) (Table A6). Here, PPARA is linked to early-onset autosomal dominant Alzheimer disease.