MALAT1 and central nervous system cancer: Interestingly, studies in glioma have inconsistent results regarding roles of MALAT1. MALAT1 expression was reported to be lower in glioma tissues than that in noncancerous brain tissues, and its higher expression correlates with better patient survival, suggesting MALAT1 may serve as an independent prognostic factor and act as a tumor suppressor in glioma [115].