CRNDE is enriched in the stem-like population of GBM cells and promotes tumor cell proliferation and migration and by sponging down miR-186 to derepressing the expression of XIAP (X-linked inhibitor of apoptosis) and PAK7 [p21 protein- (Cdc42/Rac-) activated kinase 7], two prooncogenic molecules [72]. Here, XIAP is linked to glioblastoma.