The possible pro-oncogenic functions of Smurf2 in genetically-compromised tumor cells could be related to the reported ability of Smurf2 to interfere with the RAS, Wnt/β-catenin, and EGFR-mediated signaling pathways, three central modules in cancer progression and chemoresistance (Figure 3). This evidence concerns the gene SMURF2 and neoplasm.