FDA: Food and Drug Administration; ULN: Upper limit of normal; AST: Aspartate transaminase; ALT: Alanine transaminase; VEGFR: Vascular endothelin growth factor receptor; GIST: Gastrointestinal stromal tumor; PDGFR: Platelet-derived growth factor receptor; EGFR: Epidermal growth factor receptor. The gene discussed is KDR; the disease is gastrointestinal stromal tumor.