The role of hemodynamic abnormalities and inflammatory cytokines on the CA-125 levels have been recommended in malignant, non-malignant and chronic diseases like CHF.3-7 These may also have a role in the development of atherosclerosis and its complications.14 Mechanical stress and inflammation could induce CA-125 synthesis from the mesothelial cells of the peritoneum, pleura, and pericardium.11,15 Considering these changes, CA-125 could act by inflammatory repose in CHD development and also AMI occurrence. The gene discussed is MUC16; the disease is congestive heart failure.