Lately, Zhou et al. reported that inhibition of PTEN with bpV(HOpic) aggravates ischemic acute kidney injury via augmenting apoptosis and inflammation.51 It has also reported that astrocytic PTEN loss exacerbated ischemia damage.52 Evidence has also shown that PTEN-knockout mice died in early development.16 Therefore, it is likely that the complete suppression of phosphatase activity of PTEN could not be a good idea in cell protection, particularly in this model which was made by neuroblastoma cells. The gene discussed is PTEN; the disease is neuroblastoma.