So, according to the results of SLN containing myricitrin in the present study, it could be suggested that this compound increased the compensatory action of β-cells and improved hyperglycemia concomitant with increased plasma level of insulin and was able to restore the STZ-NA-induced diabetes to a prediabetes stage, which may be a promising new treatment for the recovery and treatment of T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.