In conclusion, SLN containing myricitrin showed antidiabetic and antioxidant effects through the recovered body and tissue weight, oxidative stress, hyperglycemia, skeletal muscle glycogen content, insulin resistance, β-cell's function index, Glut-4 gene expression, and pancreas apoptosis which have been altered by STZ-NA-induced T2DM. This evidence concerns the gene SLC2A4 and Hyperglycemia.