Our above findings thus demonstrate (1) that resveratrol is able to cause oxidative stress in cancer cells, (2) that the increased ROS generation and oxidative damages are closely related with the suppressive effects of resveratrol on ATC cells, and (3) that SOD2 and CAT reduction and SULT downregulation may be responsible for ROS accumulation in resveratrol-sensitive ATC cells. The gene discussed is SOD2; the disease is cancer.