NFKB1 and Insulin resistance: For example, oxidative stress leads to the oxidation of low-density lipoproteins (LDL), and oxidized LDL (oxLDL) signals via Lox-1, RAGE, and Fas receptors to activate NF-κB and MAPKs as recently reviewed [30], and the plasma concentration of oxLDL is an independent risk factor for insulin resistance [212].