PINK1 and neuroblastoma: We have employed cellular models of mitochondrial dysfunction comprising PINK1 loss of function, namely, mouse embryonic fibroblasts (MEFs) derived from mice knockout (KO) for the PINK1 gene [37] and the neuroblastoma dopaminergic cell line SH-SY5Y where the PINK1 expression was knocked down (KD) by RNA interference [38] together with their wild type (WT) and scrambled control (SC) lines.