The current study found that the serum IL-8 elevated in patients with COPD, especially in acute phase with frequent exacerbation, and was closely associated with simultaneously elevated IL-6, TNF-α, blood eosinophils increase, and SOD reduction systematically, and also related with airway reversibility and diffuse capacity in the pulmonary part. The gene discussed is CXCL8; the disease is chronic obstructive pulmonary disease.