According to the results of the current study, it can be concluded that serum IL-8 can be a sensitive, easy-to-measure, and inexpensive biomarker to give an indication of the course of COPD during an exacerbation; and it is a target to be explored further as a predictor to distinguish the patients with COPD prone to exacerbation to implement individualized treatment and improve the disease outcome. Here, CXCL8 is linked to chronic obstructive pulmonary disease.