Considering all genetic SNPs with a mutant allele as input variables, the following SNP genotypes were found to be significantly positively associated with the risk of miscarriage: TLR9 AA (z = 4.180, p=2.92e−05), TLR9 GA (z = 4.184, p=2.87e−05), IL-10 CA (z = 3.573, p=0.000353), TLR2 GA (z = 3.027, p=0.00247), and IL-8 CT (z = 2.862, p=0.004205). The gene discussed is TLR9; the disease is spontaneous abortion.