TLR9 AA, IL-10 AA, and TLR4 CC interaction (z = 44.826, p < 0.001) and TLR9 GG, IL-10 CA, and TLR4 CT interaction (z = 44.826, p < 0.001) had a statistically significant positive effect on the risk of miscarriage. The gene discussed is TLR4; the disease is Miscarriage.