Based on the systemic immune prognostic factors identified in the multivariate analysis, we combined the two factors to establish the SIS defined as follows: patients with both high dNLR and the pretreatment hypoalbuminemia were assigned a score of 2, patients with either high dNLR or the pretreatment hypoalbuminemia were assigned a score of 1, and patients with both low dNLR and normal albumin were assigned a score of 0. The gene discussed is ALB; the disease is Hypoalbuminemia.