Risk alleles of iCHAV1 reduced ER expression; risk alleles of iCHAV1, 3 and 5 increased ESR1 expression in ER+ tumors compared with normal, tumor-adjacent tissue; Imbalance in allele-specific expression in ESR1 for SNPs in iCHAV1-3, in CCDC170 for iCHAV2 SNP rs9397437 and in RMND1 for iCHAV3 SNP rs851983; risk alleles of iCHAV3 associate with CCDC170 expression. The gene discussed is CCDC170; the disease is neoplasm.