MAP2K1 and Noonan syndrome: According to the Genecards and Malacards suites (70, 71), eight of the proteins are associated with various cancer types (GRB2, MAPK3, MAPK8, MAPK14, PRKCB, RASA1, SHC1, and SYK), four to different forms of cardiovascular diseases (MAP2K1, RAF1, RASA1, and SHC1), three to various Noonan syndromes (GAB1, MAP2K1, and RAF1), two to liver diseases (MAPK8 and SHC1), two to neuroendocrine neoplasm (MAPK3 and MAPK8), and one each to inflammatory bowel disease (SHC1), ectodermal dysplasia (IKKA), and Wiskott-Aldrich syndrome (GRB2).