By contrast, due to the downregulation of the immune-suppressive cytokine IL-10 and consequent immune imbalance caused by P17 treatment, mice showed drastic and uncontrolled pulmonary immune responses as well as infection-associated inflammation, characterized by even higher concentrations of TNF-α, IL-12p70, IFN-γ, IL-4, IL-5, and IL-17A (Figure 3D), consistent with the degrees of pulmonary injury described above. The gene discussed is TNF; the disease is infection.