UCP2 and cardiovascular disorder: Yet whether mitochondrial Ca2+ overload induced by pro-inflammatory stimuli when UCP2 expression is up-regulated, whether it is affected by the redox status (mitoROS), whether it contributes to imbalance of ER Ca2+ level, which can leads to unfolded protein response, and what is its implication in cardiovascular disease, require more detailed mechanistic study in the future.