Aside from its uncoupling and its anti-oxidative property, UCP2 also modulates various cellular energetic processes, such as fatty acid oxidation, glycolysis, and mitochondrial calcium uptake, and possibly thermoregulation, but these are relatively less well characterized when increasing attention has been given on the intrinsic cellular metabolism of vascular cells and the implication of its dysregulation in the context of cardiovascular disease. The gene discussed is UCP2; the disease is cardiovascular disorder.