Codon 72 TP53 polymorphisms have shown different associations with the risk of carcinomas in different populations, including oral carcinoma susceptibility (Tandle et al., 2001; Nagpal et al., 2002; Hsieh et al., 2005; Wang et al., 2012, 2014; Dahabreh et al., 2013; Saleem et al., 2013). This evidence concerns the gene TP53 and lip and oral cavity carcinoma.