So far many case-control studies investigated the association of functional polymorphism of TP53 codon 72 with susceptibility to oral carcinoma, but the results remain conflicting and inconclusive (Tandle et al., 2001; Nagpal et al., 2002; Hsieh et al., 2005; Wang et al., 2012; Saleem et al., 2013). This evidence concerns the gene TP53 and lip and oral cavity carcinoma.