Based on 21 case-control studies no significant association was found between TP53 Arg72Pro polymorphism and susceptibility to oral carcinoma in any genetic model (ArgPro vs. ArgArg: OR = 1.0, 95%CI = 0.90–1.11; ProPro vs. ArgArg: OR = 0.97, 95%CI = 0.84–1.12; Pro vs. Arg: OR = 1.0, 95%CI = 0.90–1.12; ArgPro+ProPro vs. ArgArg: OR = 1.01, 95%CI = 0.86–1.18; ProPro vs. ArgPro+ArgArg: OR = 0.96, 95% = 0.85–1.09). This evidence concerns the gene TP53 and lip and oral cavity carcinoma.