Previous several meta-analyses reported the lack of association between TP53 codon 72 polymorphism and the risk of oral carcinoma (Zhuo et al., 2009b; Zeng et al., 2014; Hou et al., 2015), but these studies did not stratify the conditions such as tobacco and/or alcohol uses, HPV-infection status to perform subgroup analysis. The gene discussed is TP53; the disease is lip and oral cavity carcinoma.