In addition, hyperglycemia could also modulate expression of epithelial-mesenchymal transition (EMT)-related factors in pancreatic tumor tissues, as E-cadherin level is decreased and the expression of mesenchymal markers N-cadherin and vimentin, as well as transcription factor snail, are strongly increased (Li et al., 2016). The gene discussed is CDH1; the disease is pancreatic neoplasm.