As a member of the MAPK family related to neuronal survival, JNK has been shown to increase stroke injury upon activation, and p38 signaling has been shown to exacerbate stroke-induced inflammatory responses (Barone et al., 2001; Kuan et al., 2003; Cui et al., 2007; Nithianandarajah-Jones et al., 2012). The gene discussed is MAPK8; the disease is stroke disorder.