The BAF complex is crucial for mammalian nervous system as mutations in BAF subunits have been implicated in neurological disorders such as Coffin-Siris syndrome due to mutations in BRG1 and BRM (Tsurusaki et al., 2012; Ronan et al., 2013), and SS18L1/CREST in amyotrophic lateral sclerosis (ALS) (Chesi et al., 2013). The gene discussed is SMARCA2; the disease is amyotrophic lateral sclerosis.