PPARG and fatty liver disease: Recent studies have found that diet enrichment with 5% short-chain fatty acids reduced body weight, adiposity, and hepatic steatosis in diet-induced obese mice by downregulating the activity of the nuclear receptor PPARγ [182], whereas nanoparticle-delivered acetate reduced diet-induced body weight gain, hepatic steatosis, and adiposity by enhancing hepatic mitochondrial function and inducing adipose tissue browning [190].