Ceramides, on the other hand, consist of a family of lipids structurally formed by a sphingosine base bound to a fatty acid that promote insulin resistance by two nonmutually exclusive mechanisms, involving either the allosteric activation of protein phosphatase 2A (PP2A), which dephosphorylates and inhibits Akt [136], or the activation of atypical PKC λ/ζ, which phosphorylates Akt pleckstrin domain at residue 34 impairing its translocation to the membrane and subsequent activation [137, 138]. Here, AKT1 is linked to Insulin resistance.