INS and fatty liver disease: In line with this notion, the resolvin E1 and protectin D1 were shown to improve insulin sensitivity and reduce hepatic steatosis and adipose tissue inflammation in diet-induced obese mice [178], whereas resolvin D1 improved glucose tolerance, increased adiponectin secretion, and reduced adipose tissue macrophage recruitment and formation of crown-like structures in genetically obese db/db mice [179].