IL6 and Increased total leukocyte count: It has been implicated as a critical activator of myelopoiesis in response to pathogen infection and chronic inflammation [34]; (ii) IL-1β is a potent inflammatory cytokine that mediates leukocytosis and thrombocytosis under inflammatory conditions by inducing various cytokines (i.e., granulocyte colony-stimulating factor and IL-6) [7].