With the prominent involvement of dopamine regulation in ADHD, as e.g. the dopaminergic system plays an important role in planning and initiation of motor responses, activation, switching, reaction to novelty, and reward processing [3], these molecular findings suggest a link between genetic variation in AAED1, dopaminergic and glutamatergic signaling, and ADHD risk. This evidence concerns the gene PRXL2C and attention deficit-hyperactivity disorder.