ITGAV and colorectal cancer: High ITGAV expression along with high integrin alpha-3 and alpha-6 subunits measured by immunohistochemistry, has previously been associated with reduced survival in colorectal cancer.57 The ICAM-1 low, ITGAV high phenotype seen here in pigmented melanoma that is associated with dismal survival coincided with the loss of RAB27A, a protein involved in melanosome transport and excretion.