NRAS and lymph node neoplasm: We observed a range of PMEL abundance levels in various lymph node tumor tissues (mean 7-fold difference, Supplementary Table S6), however, PMEL expression alone was not associated with differences in post-surgery MSS (p = 0.98, Fig. 4a), nor was BRAF/NRAS genotype (p = 0.69, Fig. 4b).