Using GNMT knockout mouse models (Gnmt−/−) we and another group demonstrated that Gnmt−/− mice of both genders develop HCC spontaneously at high rates and the pathology of the liver tumors mimics the multiple stages of human HCC development, including chronic hepatitis, fatty nodules, hemangioma, dysplastic nodules and HCC6–8. This evidence concerns the gene GNMT and chronic hepatitis.