Notably, one of these loci associated with uric acid concentrations and gout was the intronic rs6598541 SNP located within IGF1R encoding for the receptor of insulin-like growth factor 1 (IGF-1)22,23, and the allele of the rs6598541 SNP associated with higher serum urate concentrations (0.043 mg/dl increase [CI 0.031–0.055], P = 5 × 10−15) was also found to be associated with lower fractional excretion of uric acid (β = −0.059% increase [s.e. = 0.019], P = 1.5 × 10–3)22. The gene discussed is IGF1; the disease is gout.