XPO1 and cancer: Selective inhibitor of nuclear export (SINE) compounds (KPT-185, KPT-276, and KPT-330) were developed based on the fact that Leptomycin B specifically binds to the Cys528 residue in the cargo-binding groove of XPO1 to restore the function of TSPs in the nucleus, leading them to induce cancer-specific apoptosis7.