To directly compare our ofCS-targeting CTC isolation method with the more common EpCAM-targeting strategy, we aimed to capture CTCs in a subset of the blood samples from lung, prostate, and pancreatic cancer patients using either rVAR2-coated or anti-EpCAM antibody-coated beads on the IsoFluxTM system. Here, EPCAM is linked to pancreatic neoplasm.