In a recent study, the comparison of caudal type homeobox-2 protein (CDX2) association with sporadic or HDGC showed that all HDGC cases were negative for CDX2, whereas 19 out of 20 sporadic DGC cases showed CDX2 expression, indicating that sporadic and HDGC may arise via different molecular carcinogenic pathways [163]. The gene discussed is CDX2; the disease is Familial gastric cancer.