INS and type 1 diabetes mellitus: In addition, we found some notable pathways, including type I diabetes mellitus (ko04940), type II diabetes mellitus (ko04930), PPAR signaling pathway (ko03320), fatty acid biosynthesis (ko00061), fat digestion and absorption (ko04975), p53 signaling pathway (ko04115), insulin signaling pathway (ko04910), PI3K-Akt signaling pathway (ko04151), glycolysis/gluconeogenesis (ko00010) and insulin secretion (ko04911), were associated with these DEGs.