According to the 2016 World Health Organization (WHO) Classification based on the mutation status of isocitrate dehydrogenase (IDH) and Chromosome 1p/19q status, the diffuse gliomas are mainly divided into five subtypes, Lower grade gliomas (LGG) with IDH-mutant and 1p/19q-codeleted subtype, LGG with IDH-mutant and 1p/19q-intact subtype, LGG with IDH-wildtype subtype, GBM with IDH-mutant subtype, and GBM with IDH-wildtype subtype [3]. The gene discussed is IDH1; the disease is glioblastoma.