We used three mouse models of DS: Tg(Dyrk1a), which expresses a single additional copy of DYRK1A (Guedj et al., 2012); and Ts65Dn (Reeves et al., 1995) and Dp1Yey (Li et al., 2007), which carry MMU16 segments encompassing Dyrk1a, with 89 and 101 genes homologous to HSA21, respectively (Gupta et al., 2016). This evidence concerns the gene DYRK1A and Dravet syndrome.