In this study, we aimed to evaluate the potential of 99mTc-rhAnnexin V-128-based SPECT/CT to visualize early stages of lung remodeling in two representative mouse models of SSc-ILD, the model of bleomycin (BLM)-induced lung fibrosis [38] and the Fos-related antigen 2 (Fra-2) transgenic (tg) mouse model [39, 40]. Here, FOSL2 is linked to pulmonary fibrosis.