To evaluate the correlations between SNAP-25 and Aβ pathology, participants were dichotomized into CSF Aβ-positive (Aβ+) and Aβ-negative (Aβ–) using the previously established cutoff for CSF Aβ42 of 192 pg/ml [20]: CN Aβ– (n = 35), CN Aβ+ (n = 17), sMCI Aβ– (n = 8), sMCI Aβ+ (n = 14), pMCI Aβ– (n = 6), pMCI Aβ+ (n = 41), and AD Aβ+ (n = 18). Here, SNAP25 is linked to Alzheimer disease.