Compared with Aβ42, t-tau, and p-tau, SNAP-25 had almost the same range of diagnostic accuracy for pMCI (SNAP-25 vs Aβ42, p = 0.21; SNAP-25 vs t-tau, p = 0.60; SNAP-25 vs p-tau, p = 0.18) (Table 2 and Fig. 5a) and AD (SNAP-25 vs Aβ42, p = 0.41; SNAP-25 vs t-tau, p = 0.11; SNAP-25 vs p-tau, p = 0.07) (Table 2 and Fig. 5b). The gene discussed is MAPT; the disease is Alzheimer disease.