We also tested the hypotheses that CSF SNAP-25 levels and SNAP-25/Aβ42 ratio have associations with Aβ pathology and changes in AD cognition and brain structure, as measured by the Mini-Mental State Examination (MMSE), Alzheimer’s Disease Assessment Scale cognitive subscale (ADAS-cog), and magnetic resonance imaging (MRI). The gene discussed is SNAP25; the disease is Alzheimer disease.