Similarly, the SNAP-25/Aβ42 ratio appears to offer diagnostic accuracy at least as well as t-tau/Aβ42 and p-tau/Aβ42 for pMCI (SNAP-25/Aβ42 vs t-tau/Aβ42, p = 0.88; SNAP-25/Aβ42 vs p-tau/Aβ42, p = 0.93) (Table 2 and Fig. 5a) and AD (SNAP-25/Aβ42 vs t-tau/Aβ42, p = 0.79; SNAP-25/Aβ42 vs p-tau/Aβ42, p = 0.81) (Table 2 and Fig. 5b). This evidence concerns the gene MAPT and Alzheimer disease.