Individuals with high SNAP-25 (HR 2.47, p = 0.011), corresponding to individuals whose SNAP-25 values were ≥ 5.4 pg/ml, progressed much more rapidly to AD than individuals with lower values (< 5.4 pg/ml, corresponding to the lower median values of SNAP-25) (Fig. 6a). The gene discussed is SNAP25; the disease is Alzheimer disease.