To investigate the expression levels of KPNA2 in the glioma patients, 105 glioma tissues were collected, including 15 pilocytic astrocytomas(WHO grade I), 30 astrocytomas (WHO grade II), 30 anaplastic astrocytomas(WHO grade III) and 30 glioblastomas(WHO grade IV). This evidence concerns the gene KPNA2 and central nervous system cancer.